LY2228820

Product Name: LY2228820
CAS No.: 862507-23-1
Chemical Name: LY2228820
Synonyms: CS-371;LY2228820;LY2228820 2MsOH;Ralimetinib 2MsOH;LY2228820 USP/EP/BP;LY2228820 diMesylate;LY2228820 (mesylate);Ralimetinib Mesylate;LY2228820(LY-2228820);LY2228820 (Ralimetinib)
CBNumber: CB82518277
Molecular Formula: C26H37FN6O6S2
Formula Weight: 612.7369832
MOL File: 862507-23-1.mol

More

Less

LY2228820 Property

storage temp.: Store at -20°C
solubility: ≥30.65 mg/mL in DMSO; ≥45 mg/mL in H2O with ultrasonic; ≥9.9 mg/mL in EtOH with ultrasonic
form: solid

More

Less

Safety

HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23259
Product name: LY2228820 (mesylate)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23259
Product name: LY2228820 (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 23259
Product name: LY2228820 (mesylate)
Purity: ≥98%
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 23259
Product name: LY2228820 (mesylate)
Purity: ≥98%
Packaging: 25mg
Price: $571
Updated: 2024/03/01

TRC

Product number: L486500
Product name: LY2228820
Packaging: 50mg
Price: $1470
Updated: 2021/12/16

More

Less

LY2228820 Chemical Properties,Usage,Production

Uses

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events.

Biological Activity

ly2228820 is a potent, selective, atp-competitive small-molecule inhibitor inhibiting α- and β-isoforms of p38 mapk with ic(50) values of 5.3nm and 3.2 nm, respectively1.in multiple myeloma (mm) cell lines, ly2228820 enhanced the cytotoxicity of bortezomiba via reducing bortezomib-induced phosphorylation of heat shock protein 27 (hsp27). ly2228820 significantly reduced il-6 secretion from bm mononuclear cells (bmmncs) and long term cultured-bm stromal cells (lt-bmscs). besides, ly2228820 can also inhibit secretion of macrophage inflammatory protein-1a (mip-1a) in bmmncs, cd138+ patient mm cells and normal cd14+ osteoclast cells 2.studies in mice implanted with b16-f10 melanoma showed that orally administered ly2228820 can effectively suppress the tumor-phospho-mk2 expression. treatment of ly2228820 caused a significant tumor growth delay in a549 nsclc xenograft models1.

target

p38α

References

1. campbell rm1, anderson bd, brooks na, brooks hb, chan em, de dios a, gilmour r, graff jr, jambrina e, mader m, mccann d, na s, parsons sh, pratt se, shih c, stancato lf, starling jj, tate c, velasco ja, wang y, ye xs.characterization of ly2228820 dimesylate, a potent and selective inhibitor of p38 mapk with antitumor activity. mol cancer ther. 2014 feb;13(2):364-74.2. ishitsuka k1, hideshima t, neri p, vallet s, shiraishi n, okawa y, shen z, raje n, kiziltepe t, ocio em, chauhan d, tassone p, munshi n, campbell rm, dios ad, shih c, starling jj, tamura k, anderson kc. p38 mitogen-activated protein kinase inhibitor ly2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. br j haematol. 2008 may;141(5):598-606.

LY2228820 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LY2228820 Suppliers

China 89 India 1 United Kingdom 1 United States 16 Global 107

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

More

Less

View Lastest Price from LY2228820 manufacturers

Career Henan Chemical Co

Product: LY2228820 862507-23-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

862507-23-1, LY2228820Related Search:

LY3214996 LY2584702 LY 2784544 LY2409881 trihydrochloride LY-364947 LY 88074 (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 LY 294002 HYDROCHLORIDE Ethyl nonafluorobutyl ether (Perfluorobutyl)ethylene Methyl perfluoroisobutyl ether 2-Chloro-2-methylpropane MK-2206 2HCl Losmapimod (GW856553X) BI 2536 BIRB 796 (Doramapimod) SB 203580

5-(2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate

5-(2-(tert-butyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate

LY2228820;LY 2228820;LY-2228820

5-(2-tert-Butyl-5-(4-fluorophenyl)-1H-imidazol-4-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-am

LY2228820

5-[2-(1,1-DiMethylethyl)-5-(4-fluorophenyl)-1H-iMidazol-4-yl]-3-(2,2-diMethylpropyl)-3H-iMidazo[4,5-b]pyridin-2-aMine DiMethanesulfonate

LY2228820(LY-2228820)

LY2228820 2MsOH

LY2228820 diMesylate

5-[2-(tert-Butyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine methanesulfonate

LY2228820 (Ralimetinib) dimesylate

LY2228820 (mesylate)

Ralimetinib Mesylate

RALIMETINIB DIMESYLATE (LY2228820 DIMESYLATE)

Ralimetinib 2MsOH(LY2228820)

CS-371

LY2228820 (Ralimetinib)

RALIMETINIB DIMESYLATE; LY2228820 DIMESYLATE; LY2228820 2MSOH; LY 2228820; LY-2228820

Ralimetinib 2MsOH

LY2228820 USP/EP/BP

Ralimetinib dimysylate (LY2228820 dimysylate)

Ralimetinib mesylate LY2228820 LY-2228820

862507-23-1

C24H29FN62CH4O3S

C25H33FN6O3S

C26H37FN6O6S2

MAPK

Inhibitors

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators